SELECTION ON THE MEMPHIS ALLELE OF THE SLC4A1 GENE

picture of Kyle Patnode presenting his/her poster: SELECTION ON THE MEMPHIS ALLELE OF THE SLC4A1 GENE

Kyle Patnode , Jason Wilder Ph.D.

SELECTION ON THE MEMPHIS ALLELE OF THE SLC4A1 GENE

           The Memphis allele is a low frequency allele found in the SLC4A1 gene on chromosome 17. Memphis has an approximately even distribution (~5%) across the entire modern human population but is the wild-type allele in other primate species. The allele's continued presence in the human genome suggests the possibility that it is maintained by some form of balancing selection. Sequence data from the 1000 Genomes Project were examined for diversity. These were then compared against a neutral model of sequences generated in silico. Python scripts were developed to parse and analyze the output from simulated runs of the coalescent process. Observed results were examined for significant deviations from the neutral model using average pairwise differences (K) and Fey and Wu's H. Preliminary results suggest that the neutral model may hold, however these results fail to account for possible recent changes in selective pressure. This research was supported by NSF (1062258).

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