IMAGING OF TISSUES ASSOCIATED WITH OVARIAN CANCER USING OPTICAL COHERENCE TOMOGRAPHY

Ariel Nymeyer , Jennifer Watson, Jennifer K. Barton

IMAGING OF TISSUES ASSOCIATED WITH OVARIAN CANCER USING OPTICAL COHERENCE TOMOGRAPHY

Ovarian cancer is the fifth most common cancer in women and the leading cause of death of reproductive cancers in women with the cause currently unknown. There are currently no lab or imaging technologies able to detect ovarian cancer in the earlier stages. There is a need for a less invasive way to observe and examine the signs and symptoms of ovarian cancer. The study consists of four imaging modalities: fluorescence, optical coherence tomography (OCT), confocal microscopy, and holographic techniques, with a goal of implementing these technologies into clinical use. Tissue samples are collected from patients who have undergone an oophorectomy. The samples are taken back to the lab and imaged on the various modalities. OCT is a non-destructive modality that uses near-infrared light to create cross-sectional images of tissue with about 10 micrometer resolution and 1 millimeter depth of imaging. The OCT images have proven to show differences in patterns and structures in normal and diseased tissue. These results suggest that OCT could prove useful in clinical settings.

NIH Grant R01 CA134424

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